Publications

Selected Literature

Metabolic support by macrophages sustains colonic epithelial homeostasis. Fritsch SD, Sukhbaatar N, Gonzales K, Sahu A, Tran L, Vogel A, Mazic M, Wilson JL, Forisch S, Mayr H, Oberle R, Weiszmann J, Brenner M, Vanhoutte R, Hofmann M, Pirnes-Karhu S, Magnes C, Kühnast T, Weckwerth W, Bock C, Klavins K, Hengstschläger M, Moissl-Eichinger C, Schabbauer G, Egger G, Pirinen E, Verhelst SHL, Weichhart T.
Cell Metab. 2023 Sep 29:S1550-4131(23)00341-8. https://doi.org/10.1016/j.cmet.2023.09.010 PMID:37804836

 

Duodenal macrophages control dietary iron absorption via local degradation of transferrin. Sukhbaatar N, Schöller M, Fritsch SD, Linke M, Horer S, Träger M, Mazic M, Forisch S, Gonzales K, Kahler JP, Binder C, Lassnig C, Strobl B, Mueller M, Scheiber-Mojdehkar B, Gundacker C, Dabsch S, Kain R, Hengstschläger M, Verhelst S, Weiss G, Theurl I, Weichhart T.
Blood 2023 Apr 5:blood.2022016632. https://doi.org/10.1182/blood.2022016632 PMID:37018657

 

Chronic signaling via the metabolic checkpoint kinase mTORC1 induces macrophage granuloma formation and marks sarcoidosis progression. Linke M, Pham HT, Katholnig K, Schnöller T, Miller A, Demel F, Schütz B, Rosner M, Kovacic B, Sukhbaatar N, Niederreiter B, Blüml S, Kuess P, Sexl V, Müller M, Mikula M, Weckwerth W, Haschemi A, Susani M, Hengstschläger M, Gambello MJ, Weichhart T.
Nat Immunol 2017. 18:293–302. https://doi.org/10.1038/ni.3655 PMID:28092373

 

Aberrant Lipid Metabolism in Macrophages Is Associated with Granuloma Formation in Sarcoidosis. Lim CX, Redl A, Kleissl L, Pandey RV, Mayerhofer C, El Jammal T, Mazic M, Gonzales K, Sukhbaatar N, Krausgruber T, Bock C, Hengstschläger M, Calender A, Pacheco Y, Stary G, Weichhart T.
Am J Respir Crit Care Med 2024 Feb 14. https://doi.org/10.1164/rccm.202307-1273OC PMID:38353578

 

Inactivation of mTORC2 in macrophages is a signature of colorectal cancer that promotes tumorigenesis. Katholnig K, Schütz B, Fritsch SD, Schörghofer D, Linke M, Sukhbaatar N, Matschinger JM, Unterleuthner D, Hirtl M, Lang M, Herac M, Spittler A, Bergthaler A, Schabbauer G, Bergmann M, Dolznig H, Hengstschläger M, Magnuson MA, Mikula M, Weichhart T.
JCI Insight 2019. 14(20). pii: 124164. https://doi.org/10.1172/jci.insight.124164 PMID:1619583

 

Regulation of innate immune cell function by mTOR. Weichhart T, Hengstschläger M, Linke M.
Nat Rev Immunol 2015. 15:599–614. https://doi.org/10.1038/nri3901 PMID:26403194

 


Peer reviewed original publications

Targeting PHGDH reverses the immunosuppressive phenotype of tumor-associated macrophages through α-ketoglutarate and mTORC1 signaling. Cai Z, Li W, Hager S, Wilson JL, Afjehi-Sadat L, Heiss EH, Weichhart T, Heffeter P, Weckwerth W. Cell Mol Immunol 2024 Feb 27. https://doi.org/10.1038/s41423-024-01134-0 PMID:38409249

 

Aberrant Lipid Metabolism in Macrophages Is Associated with Granuloma Formation in Sarcoidosis. Lim CX, Redl A, Kleissl L, Pandey RV, Mayerhofer C, El Jammal T, Mazic M, Gonzales K, Sukhbaatar N, Krausgruber T, Bock C, Hengstschläger M, Calender A, Pacheco Y, Stary G, Weichhart T. Am J Respir Crit Care Med 2024 Feb 14. https://doi.org/10.1164/rccm.202307-1273OC PMID:38353578

 

R-ketorolac ameliorates cancer-associated cachexia and prolongs survival of tumour-bearing mice. Chrysostomou SE, Eder S, Pototschnig I, Mayer AL, Derler M, Mussbacher M, Schauer S, Zhang D, Yan D, Liu G, Hoefler G, Weichhart T, Vesely PW, Zhang L, Schweiger M. J Cachexia Sarcopenia Muscle 2024 Feb 1. https://doi.org/10.1002/jcsm.13422 PMID:38302863

 

Efficacy and safety of mTOR inhibition in cutaneous sarcoidosis: a single-centre trial. Redl A, Doberer K, Unterluggauer L, Kleissl L, Krall C, Mayerhofer C, Reininger B, Stary V, Zila N, Weninger W, Weichhart T, Bock C, Krausgruber T, Stary G. Lancet Rheumatol 2024 Feb;6(2):e81-e91. https://doi.org/10.1016/S2665-9913(23)00302-8 PMID:38267106

 

Metabolic support by macrophages sustains colonic epithelial homeostasis. Fritsch SD, Sukhbaatar N, Gonzales K, Sahu A, Tran L, Vogel A, Mazic M, Wilson JL, Forisch S, Mayr H, Oberle R, Weiszmann J, Brenner M, Vanhoutte R, Hofmann M, Pirnes-Karhu S, Magnes C, Kühnast T, Weckwerth W, Bock C, Klavins K, Hengstschläger M, Moissl-Eichinger C, Schabbauer G, Egger G, Pirinen E, Verhelst SHL, Weichhart T. Cell Metabolism 2023 Sep 29:S1550-4131(23)00341-8. https://doi.org/10.1016/j.cmet.2023.09.010 PMID:37804836

 

An mTORC1-Dependent Mouse Model for Cardiac Sarcoidosis. Bueno-Beti C, Lim CX, Protonotarios A, Szabo PL, Westaby J, Mazic M, Sheppard MN, Behr E, Hamza O, Kiss A, Podesser BK, Hengstschläger M, Weichhart T, Asimaki A. J Am Heart Assoc 2023 Oct 3;12(19):e030478. doi: . https://doi.org/10.1161/JAHA.123.030478 PMID:37750561

 

SHP2 promotes sarcoidosis severity by inhibiting SKP2-targeted ubiquitination of TBET in CD8+ T cells. Celada SI, Lim CX, Carisey AF, Ochsner SA, Arce Deza CF, Rexie P, Poli De Frias F, Cardenas-Castillo R, Polverino F, Hengstschläger M, Tsoyi K, McKenna NJ, Kheradmand F, Weichhart T, Rosas IO, Van Kaer L, Celada LJ. Sci Transl Med 2023 Sep 13;15(713):eade2581. https://doi.org/10.1126/scitranslmed.ade2581 PMID:37703351

 

Duodenal macrophages control dietary iron absorption via local degradation of transferrin. Sukhbaatar N, Schöller M, Fritsch SD, Linke M, Horer S, Träger M, Mazic M, Forisch S, Gonzales K, Kahler JP, Binder C, Lassnig C, Strobl B, Mueller M, Scheiber-Mojdehkar B, Gundacker C, Dabsch S, Kain R, Hengstschläger M, Verhelst S, Weiss G, Theurl I, Weichhart T. Blood 2023 Apr 5:blood.2022016632. https://doi.org/10.1182/blood.2022016632 PMID:37018657

 

Single-cell and spatial transcriptomics reveal aberrant lymphoid developmental programs driving granuloma formation. Krausgruber T, Redl A, Barreca D, Doberer K, Romanovskaia D, Dobnikar L, Guarini M, Unterluggauer L, Kleissl L, Atzmüller D, Mayerhofer C, Kopf A, Saluzzo S, Lim CX, Rexie P, Weichhart T, Bock C, Stary G. Immunity 2023 Feb 6:S1074-7613(23)00024-9. https://doi.org/10.1016/j.immuni.2023.01.014 PMID:36750099

 

Interleukin-6 initiates muscle- and adipose tissue wasting in a novel C57BL/6 model of cancer-associated cachexia. Pototschnig I, Feiler U, Diwoky C, Vesely PW, Rauchenwald T, Paar M, Bakiri L, Pajed L, Hofer P, Kashofer K, Sukhbaatar N, Schoiswohl G, Weichhart T, Hoefler G, Bock C, Pichler M, Wagner EF, Zechner R, Schweiger M. J Cachexia Sarcopenia Muscle 2022 Nov 9. https://doi.org/10.1002/jcsm.13109 PMID:36351437

 

PTX3 Inhibits Complement-Driven Macrophage Activation to Restrain Granuloma Formation in Sarcoidosis. Gonçales RA, Bastos HN, Duarte-Oliveira C, Antunes D, Sokhatska O, Jacob M, Rolo R, Campos CF, Sasaki SD, Donato A, Mapelli SN, Costa S, Moura CS, Delgado L, Morais A, Torrado E, van de Veerdonk FL, Weichhart T, Lambris JD, Silvestre R, Garlanda C, Mantovani A, Cunha C, Carvalho A. Am J Respir Crit Care Med 2022 Jun 29. https://doi.org/10.1164/rccm.202112-2771OC PMID:35767663

 

Inhibition of mTOR in bovine monocyte derived macrophages and dendritic cells provides a potential mechanism for postpartum immune dysfunction in dairy cows. Sipka AS, Chandler TL, Weichhart T, Schuberth HJ, Mann S. Sci Rep 2022 Sep 5;12(1):15084. https://doi.org/10.1038/s41598-022-19295-1PMID:36064574

 

Pharmacological inhibition of the mTOR pathway alters phenotype and cytokine expression in bovine monocyte-derived dendritic cells. Sipka A, Weichhart T, Mann S. Vet Immunol Immunopathol. 2022 Jul; 249:110441. https://doi.org/10.1016/j.vetimm.2022.110441 PMID:35597229

 

Activation of Downstream mTORC1 Target Ribosomal Protein S6 Kinase (S6K) Can Be Found in a Subgroup of Dutch Patients with Granulomatous Pulmonary Disease. Kraaijvanger R, Seldenrijk K, Beijer E, Damen J, Wilson JL, Weichhart T, Grutters JC, Veltkamp M. Cells 2021 Dec 15;10(12):3545. https://doi.org/110.3390/cells10123545 PMID:34944053

 

p38 regulates the tumor suppressor PDCD4 via the TSC-mTORC1 pathway. Braun C, Katholnig K, Kaltenecker C, Linke M, Sukhbaatar N, Hengstschläger M, Weichhart T. Cell Stress 2021 Nov 23;5(12):176-182. https://doi.org/10.15698/cst2021.12.260 PMID:34917890

 

24-NorUrsodeoxycholic acid reshapes immunometabolism in CD8 + T-cells and alleviates hepatic inflammation. Zhu C, Boucheron N, Müller AC, Májek P, Claudel T, Halilbasic E, Baazim H, Lercher A, Viczenczova C, Hainberger D, Preglej T, Sandner L, Alteneder M, Gülich AF, Khan M, Hamminger P, Remetic J, Ohradanova-Repic A, Schatzlmaier P, Donner C, Fuchs CD, Stojakovic T, Scharnagl H, Sakaguchi S, Weichhart T, Bergthaler A, Stockinger H, Ellmeier W, Trauner M. J Hepatol 2021. Jul 6. https://doi.org/10.1016/j.jhep.2021.06.036 PMID:34242699

 

High expression of mTOR signaling in granulomatous lesions is not predictive for the clinical course of sarcoidosis. Pizzini A, Bacher H, Aichner M, Franchi A, Watzinger K, Tancevski I, Sonnweber T, Mosheimer-Feistritzer B, Duftner C, Zelger B, Pallua J, Sprung S, Weichhart T, Zelger B, Weiss G, Löffler-Ragg J. Respir Med 2021 Jan 5;177:106294. https://doi.org/10.1016/j.rmed.2020.106294 PMID:33485108

 

The PI3K pathway preserves metabolic health through MARCO-dependent lipid uptake by adipose tissue macrophages. Brunner JS, Vogel A, Lercher A, Caldera M, Korosec A, Pühringer M, Hofmann M, Hajto A, Kieler M, Garrido LQ, Kerndl M, Kuttke M, Mesteri I, Górna MW, Kulik M, Dominiak PM, Brandon AE, Estevez E, Egan CL, Gruber F, Schweiger M, Menche J, Bergthaler A, Weichhart T, Klavins K, Febbraio MA, Sharif O, Schabbauer G. Nat Metabolism 2020. Nov 16. https://doi.org/10.1038/s42255-020-00311-5 PMID:33199895

 

Inverse Data-Driven Modeling and Multiomics Analysis Reveals Phgdh as a Metabolic Checkpoint of Macrophage Polarization and Proliferation. Wilson JL, Nägele T, Linke M, Demel F, Fritsch SD, Mayr HK, Cai Z, Katholnig K, Sun X, Fragner L, Miller A, Haschemi A, Popa A, Bergthaler A, Hengstschläger M, Weichhart T, Weckwerth W. Cell Rep 2020. Feb 4;30(5):1542-1552.e7. https://doi.org/10.1016/j.celrep.2020.01.011 PMID:32023468

 

Environmental arginine controls multinuclear giant cell metabolism and formation. Brunner JS, Vulliard L, Hofmann M, Kieler M, Lercher A, Vogel A, Russier M, Brüggenthies JB, Kerndl M, Saferding V, Niederreiter B, Junza A, Frauenstein A, Scholtysek C, Mikami Y, Klavins K, Krönke G, Bergthaler A, O'Shea JJ, Weichhart T, Meissner F, Smolen JS, Cheng P, Yanes O, Menche J, Murray PJ, Sharif O, Blüml S, Schabbauer G. Nat Commun 2020. Jan 22;11(1):431. https://doi.org/10.1038/s41467-020-14285-1 PMID:31969567

 

A kinase-independent role for CDK8 in BCR-ABL1+ leukemia. Menzl I, Zhang T, Berger-Becvar A, Grausenburger R, Heller G, Prchal-Murphy M, Edlinger L, Knab VM, Uras IZ, Grundschober E, Bauer K, Roth M, Skucha A, Liu Y, Hatcher JM, Liang Y, Kwiatkowski NP, Fux D, Hoelbl-Kovacic A, Kubicek S, Melo JV, Valent P, Weichhart T, Grebien F, Zuber J, Gray NS, Sexl V. Nat Commun 2019. 10:4741. https://doi.org/10.1038/s41467-019-12656-x PMID:31628323

 

Inactivation of mTORC2 in macrophages is a signature of colorectal cancer that promotes tumorigenesis. Katholnig K, Schütz B, Fritsch SD, Schörghofer D, Linke M, Sukhbaatar N, Matschinger JM, Unterleuthner D, Hirtl M, Lang M, Herac M, Spittler A, Bergthaler A, Schabbauer G, Bergmann M, Dolznig H, Hengstschläger M, Magnuson MA, Mikula M, Weichhart T. JCI Insight. 2019.14(20). pii: 124164. https://doi.org/10.1172/jci.insight.124164 PMID:1619583

 

Exome sequencing and pathogenicity-network analysis of 5 French families implicate mTOR signalling and autophagy in familial sarcoidosis. Calender A, Lim CX, Weichhart T, Buisson A, Besnard V, Rollat-Farnier PA, Bardel C, Roy P, Cottin V, Devouassoux G, Finat A, Pinson S, Lebecque S, Nunes H, Israel-Biet D, Bentaher A, Valeyre D, Pacheco Y; in the frame of GSF (Group Sarcoidosis France). Eur Respir J. 2019. Apr 25. pii: 1900430. https://doi.org/10.1183/13993003.00430-2019 PMID:31023854

 

mTOR Senses Environmental Cues to Shape the Fibroblast-like Synoviocyte Response to Inflammation. Karonitsch T, Kandasamy RK, Kartnig F, Herdy B, Dalwigk K, Niederreiter B, Holinka J, Sevelda F, Windhager R, Bilban M, Weichhart T, Säemann M, Pap T, Steiner G, Smolen JS, Kiener HP, Superti-Furga G. Cell Rep 2018. 23:2157-2167. https://doi.org/10.1016/j.celrep.2018.04.044 PMID:29768212

 

Whole exome sequencing in three families segregating a pediatric case of sarcoidosis. Calender A, Rollat Farnier PA, Buisson A, Pinson S, Bentaher A, Lebecque S, Corvol H, Abou Taam R, Houdouin V, Bardel C, Roy P, Devouassoux G, Cottin V, Seve P, Bernaudin JF, Lim CX, Weichhart T, Valeyre D, Pacheco Y, Clement A, Nathan N; in the frame of GSF (Groupe Sarcoïdose France). BMC Med Genomics 2018. 11:23. https://doi.org/10.1186/s12920-018-0338-x PMID:29510755

 

Pro- versus Anti-inflammatory Actions of HDLs in Innate Immunity. Kopecky C, Michlits G, Säemann MD, Weichhart T. Cell Metab 2017. 26:2-3. https://doi.org/10.1016/j.cmet.2017.04.007 PMID:28648980

 

A New Immunomodulatory Role for Peroxisomes in Macrophages Activated by the TLR4 Ligand Lipopolysaccharide. Vijayan V, Srinu T, Karnati S, Garikapati V, Linke M, Kamalyan L, Mali SR, Sudan K, Kollas A, Schmid T, Schulz S, Spengler B, Weichhart T, Immenschuh S, Baumgart-Vogt E. J Immunol 2017. 198:2414–2425. https://doi.org/10.4049/jimmunol.1601596 PMID:28179495

 

HDL Cholesterol Efflux Does Not Predict Cardiovascular Risk in Hemodialysis Patients. Kopecky C, Ebtehaj S, Genser B, Drechsler C, Krane V, Antlanger M, Kovarik JJ, Kaltenecker CC, Parvizi M, Wanner C, Weichhart T, Säemann MD, Tietge UJ. J Am Soc Nephrol 2017. 28:769–775. https://doi.org/10.1681/ASN.2016030262 PMID:27612996

 

Chronic signaling via the metabolic checkpoint kinase mTORC1 induces macrophage granuloma formation and marks sarcoidosis progression. Linke M, Pham HT, Katholnig K, Schnöller T, Miller A, Demel F, Schütz B, Rosner M, Kovacic B, Sukhbaatar N, Niederreiter B, Blüml S, Kuess P, Sexl V, Müller M, Mikula M, Weckwerth W, Haschemi A, Susani M, Hengstschläger M, Gambello MJ, Weichhart T. Nat Immunol 2017. 18:293–302. https://doi.org/10.1038/ni.3655 PMID:28092373

 

Applied immuno-epidemiological research: an approach for integrating existing knowledge into the statistical analysis of multiple immune markers. Genser B, Fischer JE, Figueiredo CA, Alcântara-Neves N, Barreto ML, Cooper PJ, Amorim LD, Saemann MD, Weichhart T, Rodrigues LC. BMC Immunol 2016. 17:11. https://doi.org/10.1186/s12865-016-0149-9 PMID:27206492

 

Effects of the mTOR inhibitor everolimus and the PI3K/mTOR inhibitor NVP-BEZ235 in murine acute lung injury models. Üstün S, Lassnig C, Preitschopf A, Mikula M, Müller M, Hengstschläger M, Weichhart T. 2015. Transpl Immunol 2015. 33:45–50. https://doi.org/10.1016/j.trim.2015.06.001 PMID:26073719

 

Quantification of HDL proteins, cardiac events, and mortality in patients with type 2 diabetes on hemodialysis. Kopecky C, Genser B, Drechsler C, Krane V, Kaltenecker CC, Hengstschläger M, März W, Wanner C, Säemann MD, Weichhart T. Clin J Am Soc Nephrol 2015. 10:224–231. https://doi.org/10.2215/CJN.06560714 PMID:25424990

 

mTORC1 is essential for early steps during Schwann cell differentiation of amniotic fluid stem cells and regulates lipogenic gene expression. Preitschopf A, Li K, Schörghofer D, Kinslechner K, Schütz B, Thi Thanh Pham H, Rosner M, Joo GJ, Röhrl C, Weichhart T, Stangl H, Lubec G, Hengstschläger M, Mikula M. PLoS One 2014. 9:e107004. https://doi.org/10.1371/journal.pone.0107004 PMID:25221943

 

Restoration of Renal Function Does Not Correct Impairment of Uremic HDL Properties. Kopecky C, Haidinger M, Birner-Grünberger R, Darnhofer B, Kaltenecker CC, Marsche G, Holzer M, Weichhart T, Antlanger M, Kovarik JJ, Werzowa J, Hecking M, Säemann MD. J Am Soc Nephrol 2015. 26:565-75.https://doi.org/10.1681/ASN.2013111219 PMID:25071090

 

Expression, Reduces Endothelial Cell Migration and Impairs Nitric Oxide Production. Fruhwürth S, Krieger S, Winter K, Rosner M, Mikula M, Weichhart T, Bittman R, Hengstschläger M, Stangl H. Inhibition of mTOR Down-regulates Scavenger Receptor, Class B, Type I (SR-BI) Biochim Biophys Acta 2014. 1841:944-53. https://doi.org/10.1016/j.bbalip.2014.03.014 PMID:24713582

 

Hereditary amyloidosis caused by R554L fibrinogen Aα-chain mutation in a Spanish family and review of the literature. Haidinger M, Werzowa J, Kain R, Antlanger M, Hecking M, Pfaffenberger S, Mascherbauer J, Gremmel T, Gilbertson JA, Rowczenio D, Weichhart T, Kopecky C, Hörl WH, Hawkins PN, Säemann MD. Amyloid 2013. 20:72–79. https://doi.org/10.3109/13506129.2013.781998 PMID:23551149

 

p38α senses environmental stress to control innate immune responses via mTOR. Katholnig K, Kaltenecker CC, Hayakawa H, Rosner M, Lassnig C, Zlabinger GJ, Gaestel M, Müller M, Hengstschläger M, Hörl WH, Park JM, Säemann MD, Weichhart T. J Immunol 2013. 190:1519–1527. https://doi.org/10.4049/jimmunol.1202683 PMID:23315073

 

PDGFR blockade is a rational and effective therapy for NPM-ALK-driven lymphomas. Laimer D, Dolznig H, Kollmann K, Vesely PW, Schlederer M, Merkel O, Schiefer AI, Hassler MR, Heider S, Amenitsch L, Thallinger C, Staber PB, Simonitsch-Klupp I, Artaker M, Lagger S, Turner SD, Pileri S, Piccaluga PP, Valent P, Messana K, Landra I, Weichhart T, Knapp S, Shehata M, Todaro M, Sexl V, Höfler G, Piva R, Medico E, Ruggeri BA, Cheng M, Eferl R, Egger G, Penninger JM, Jaeger U, Moriggl R, Inghirami G, Kenner L. Nat Med 2012. 18:1699–1704. https://doi.org/10.1038/nm.2966 PMID:23064464

 

Blood volume-monitored regulation of ultrafiltration in fluid-overloaded hemodialysis patients: study protocol for a randomized controlled trial. Hecking M, Antlanger M, Winnicki W, Reiter T, Werzowa J, Haidinger M, Weichhart T, Polaschegg HD, Josten P, Exner I, Lorenz-Turnheim K, Eigner M, Paul G, Klauser-Braun R, Hörl WH, Sunder-Plassmann G, Säemann MD. Trials 2012. 13:79. https://doi.org/10.1186/1745-6215-13-79 PMID:22682149

 

CMV late phase-induced mTOR activation is essential for efficient virus replication in polarized human macrophages. Poglitsch M, Weichhart T, Hecking M, Werzowa J, Katholnig K, Antlanger M, Krmpotic A, Jonjic S, Hörl WH, Zlabinger GJ, Puchhammer E, Säemann MD. Am J Transplant 2012. 12:1458–1468. https://doi.org/10.1111/j.1600-6143.2012.04002.x PMID:22390651

 

Serum amyloid A in uremic HDL promotes inflammation. Weichhart T, Kopecky C, Kubicek M, Haidinger M, Döller D, Katholnig K, Suarna C, Eller P, Tölle M, Gerner C, Zlabinger GJ, van der Giet M, Hörl WH, Stocker R, Säemann MD. J Am Soc Nephrol 2012. 23:934–947. https://doi.org/10.1681/ASN.2011070668 PMID:22282592

 

Apoptotic cell-free DNA promotes inflammation in haemodialysis patients. Atamaniuk J, Kopecky C, Skoupy S, Säemann MD, Weichhart T. Nephrol Dial Transplant 2012. 27:902–905. https://doi.org/10.1093/ndt/gfr695 PMID:22167588

 

Rapid isolation of nuclei from living immune cells by a single centrifugation through a multifunctional lysis gradient. Poglitsch M, Katholnig K, Säemann MD, Weichhart T. J Immunol Methods 2011. 373:167–173. https://doi.org/10.1016/j.jim.2011.08.012 PMID:21889513

 

Inhibition of mTOR blocks the anti-inflammatory effects of glucocorticoids in myeloid immune cells. Weichhart T, Haidinger M, Katholnig K, Kopecky C, Poglitsch M, Lassnig C, Rosner M, Zlabinger GJ, Hengstschläger M, Müller M, Hörl WH, Säemann MD. Blood 2011. 117:4273–4283. https://doi.org/10.1182/blood-2010-09-310888 PMID:21368289

 

A randomized, placebo-controlled, double-blind, prospective trial to evaluate the effect of vildagliptin in new-onset diabetes mellitus after kidney transplantation. Haidinger M, Werzowa J, Voigt HC, Pleiner J, Stemer G, Hecking M, Döller D, Hörl WH, Weichhart T, Säemann MD. Trials 2010. 11:91. https://doi.org/10.1186/1745-6215-11-91 PMID:20925938

 

A versatile role of mammalian target of rapamycin in human dendritic cell function and differentiation. Haidinger M, Poglitsch M, Geyeregger R, Kasturi S, Zeyda M, Zlabinger GJ, Pulendran B, Hörl WH, Säemann MD, Weichhart T. J Immunol 2010. 185:3919–3931. https://doi.org/10.4049/jimmunol.1000296 PMID:20805416

 

Effect of the proteasome inhibitor bortezomib on humoral immunity in two presensitized renal transplant candidates. Wahrmann M, Haidinger M, Körmöczi GF, Weichhart T, Säemann MD, Geyeregger R, Kikić Z, Prikoszovich T, Drach J, Böhmig GA. Transplantation 2010. 89:1385–1390. https://doi.org/10.1097/TP.0b013e3181d9e1c0 PMID:20335829

 

Neutralization of osteopontin inhibits obesity-induced inflammation and insulin resistance. Kiefer FW, Zeyda M, Gollinger K, Pfau B, Neuhofer A, Weichhart T, Säemann MD, Geyeregger R, Schlederer M, Kenner L, Stulnig TM. Diabetes 2010. 59:935–946. https://doi.org/10.2337/db09-0404 PMID:20107108

 

Sirolimus in renal transplant recipients with tuberous sclerosis complex: clinical effectiveness and implications for innate immunity. Haidinger M, Hecking M, Weichhart T, Poglitsch M, Enkner W, Vonbank K, Prayer D, Geusau A, Oberbauer R, Zlabinger GJ, Soleiman A, Hörl WH, Säemann MD. Transpl Int 2010. 23:777–785. https://doi.org/10.1111/j.1432-2277.2009.01041.x PMID:20070623

 

The anti-inflammatory potency of dexamethasone is determined by the route of application in vivo. Weichhart T, Brandt O, Lassnig C, Müller M, Hörl WH, Stingl G, Säemann MD. Immunol Lett 2010. 129:50–52. https://doi.org/10.1016/j.imlet.2009.12.025 PMID:20060857

 

Late onset Pneumocystis pneumonia in renal transplantation after long-term immunosuppression with belatacept. Haidinger M, Hecking M, Memarsadeghi M, Weichhart T, Werzowa J, Hörl WH, Säemann MD. Transpl Infect Dis 2009. 11:171–174. https://doi.org/10.1111/j.1399-3062.2009.00366.x PMID:19210692

 

The TSC-mTOR signaling pathway regulates the innate inflammatory response. Weichhart T, Costantino G, Poglitsch M, Rosner M, Zeyda M, Stuhlmeier KM, Kolbe T, Stulnig TM, Hörl WH, Hengstschläger M, Müller M, Säemann MD. Immunity 2008. 29:565–577. https://doi.org/10.1016/j.immuni.2008.08.012 PMID:18848473

 

Biological action of rapamycin in renal transplantation. Weichhart T, Werzowa J, Hörl WH, Säemann MD. Am J Kidney Dis 2008. 51:531, author reply 531–532. https://doi.org/10.1053/j.ajkd.2007.09.027 PMID:18295073

 

Osteopontin expression in human and murine obesity: extensive local up-regulation in adipose tissue but minimal systemic alterations. Kiefer FW, Zeyda M, Todoric J, Huber J, Geyeregger R, Weichhart T, Aszmann O, Ludvik B, Silberhumer GR, Prager G, Stulnig TM. Endocrinology 2008. 149:1350–1357. https://doi.org/10.1210/en.2007-1312 PMID:18048491

 

Identification of the scavenger receptors SREC-I, Cla-1 (SR-BI), and SR-AI as cellular receptors for Tamm-Horsfall protein. Pfistershammer K, Klauser C, Leitner J, Stöckl J, Majdic O, Weichhart T, Sobanov Y, Bochkov V, Säemann M, Zlabinger G, Steinberger P. J Leukoc Biol 2008. 83:131–138. https://doi.org/10.1189/jlb.0407231 PMID:17928461

 

Antithymocyte globulin impairs T-cell/antigen-presenting cell interaction: disruption of immunological synapse and conjugate formation. Haidinger M, Geyeregger R, Poglitsch M, Weichhart T, Zeyda M, Vodenik B, Stulnig TM, Böhmig GA, Hörl WH, Säemann MD. Transplantation 2007.84:117–121. https://doi.org/10.1097/01.tp.0000266677.45428.80 PMID:17627247

 

Toll-like receptors and chondrocytes: the LPS induced decrease in cartilage mytrix synthesis is dependent on the presence of Toll-like receptor-4 and is antagonized by bone morphogenetic protein-7. Bobacz K, Sunk IG, Amoyo L, Akira S, Weichhart T, Säemann MD, Smolen JS. Arthritis Rheum 2007. 56:1880–1893. https://doi.org/10.1002/art.22637 PMID:17530716

 

Prevention of high-fat diet-induced adipose tissue remodeling in obese diabetic mice by n-3 polyunsaturated fatty acids. Huber J, Löffler M, Bilban M, Reimers M, Kadl A, Todoric J, Zeyda M, Geyeregger R, Schreiner M, Weichhart T, Leitinger N, Waldhäusl W, Stulnig TM. Int J Obes 2007. 31:1004–1013. https://doi.org/10.1038/sj.ijo.0803511 PMID:17130847

 

Impairment of T cell interactions with antigen-presenting cells by immunosuppressive drugs reveals involvement of calcineurin and NF-kappaB in immunological synapse formation. Zeyda M, Geyeregger R, Poglitsch M, Weichhart T, Zlabinger GJ, Koyasu S, Hörl WH, Stulnig TM, Watschinger B, Säemann MD. J Leukoc Biol 2007. 81:319–327. https://doi.org/10.1189/jlb.0606378 PMID:17038582

 

Tamm-Horsfall glycoprotein links innate immune cell activation with adaptive immunity via a Toll-like receptor-4-dependent mechanism. Säemann MD, Weichhart T, Zeyda M, Staffler G, Schunn M, Stuhlmeier KM, Sobanov Y, Stulnig TM, Akira S, von Gabain A, von Ahsen U, Hörl WH, Zlabinger GJ. J Clin Invest 2005. 115:468–475. https://doi.org/10.1172/JCI200522720 PMID:15650774

 

Functional selection of vaccine candidate peptides from Staphylococcus aureus whole-genome expression libraries in vitro. Weichhart T, Horky M, Söllner J, Gangl S, Henics T, Nagy E, Meinke A, von Gabain A, Fraser CM, Gill SR, Hafner M, von Ahsen U. Infect Immun 2003. 71:4633–4641. https://doi.org/10.1128/IAI.71.8.4633-4641.2003 PMID:12874343

 


Reviews

Exploring the human archaeome: its relevance for health and disease, and its complex interplay with the human immune system. Kuehnast T, Kumpitsch C, Mohammadzadeh R, Weichhart T, Moissl-Eichinger C, Heine H. FEBS J 2024 Mar 31. https://doi.org/10.1111/febs.17123 PMID: 38555566

 

Leveraging macrophage metabolism for anticancer therapy: opportunities and pitfalls. Saha P, Ettel P, Weichhart T. Trends Pharmacol Sci 2024 Mar 16:S0165-6147(24)00045-2. https://doi.org/10.1016/j.tips.2024.02.005 PMID: 38494408

 

Not just sugar: Metabolic control of neutrophil development and effector functions. Ettel P, Weichhart T. J Leukoc Biol 2024 Mar 7:qiae057. https://doi.org/10.1093/jleuko/qiae057 PMID: 38450755

 

Tissue-resident macrophages - early passengers or drivers in the tumor niche? Vogel A, Weichhart T. Curr Opin Biotechnol 2023 Oct;83:102984. https://doi.org/10.1016/j.copbio.2023.102984 PMID:37572419

 

mTOR-dependent immunometabolism as Achilles' heel of anticancer therapy. Braun C, Weichhart T. Eur J Immunol 2021 Dec;51(12):3161-3175. https://doi.org/10.1002/eji.202149270 PMID:34648202

 

Current Insights in Genetics of Sarcoidosis: Functional and Clinical Impacts. Calender A, Weichhart T, Valeyre D, Pacheco Y. J Clin Med 2020. 9(8):E2633. https://doi.org/10.3390/jcm9082633 PMID:32823753

 

Metabolic and immunologic control of intestinal cell function by mTOR. Fritsch SD, Weichhart T. Int Immunol 2020. 32(7):455-465. https://doi.org/10.1093/intimm/dxaa015 PMID:32140726

 

Sarcoidosis and the mTOR, Rac1, and Autophagy Triad. Pacheco Y, Lim CX, Weichhart T, Valeyre D, Bentaher A, Calender A. Trends Immunol 2020. 41(4):286-299. https://doi.org/10.1016/j.it.2020.01.007 PMID:32122794

 

Metabolic Programming of Macrophages: Implications in the Pathogenesis of Granulomatous Disease. Wilson JL, Mayr HK, Weichhart T. Front Immunol. 2019. 10:2265. https://doi.org/10.3389/fimmu.2019.02265 PMID:31681260

 

Iron Regulation: Macrophages in Control. Sukhbaatar N, Weichhart T. Pharmaceuticals (Basel) 2018. 14;11(4). https://doi.org/10.3390/ph11040137 PMID:30558109

 

mTOR as Regulator of Lifespan, Aging, and Cellular Senescence: A Mini-Review. Weichhart T. Gerontology 2018. 64:127-134. https://doi.org/10.1159/000484629 PMID:29190625

 

mTORC1 and mTORC2 as regulators of cell metabolism in immunity. Linke M, Fritsch SD, Sukhbaatar N, Hengstschläger M, Weichhart T. FEBS Lett 2017. 591:3089–3103. https://doi.org/10.1002/1873-3468.12711 PMID:28600802

 

Effects of interferons and viruses on metabolism. Fritsch S, Weichhart T. Frontiers Immunol 2016. 7:630. https://doi.org/10.3389/fimmu.2016.00630 PMID:28066439

 

mTOR-mediated regulation of dendritic cell differentiation and function. Sukhbaatar N, Hengstschläger M, Weichhart T. Trends Immunol 2016. 37:778-789. https://doi.org/10.1016/j.it.2016.08.009 PMID:27614799

 

Regulation of innate immune cell function by mTOR. Weichhart T, Hengstschläger M, Linke M. Nat Rev Immunol 2015. 15:599–614. https://doi.org/10.1038/nri3901 PMID:26403194

 

Drug-induced pneumonitis in cancer patients treated with mTOR inhibitors: management and insights into possible mechanisms. Duran I, Goebell PJ, Papazisis K, Ravaud A, Weichhart T, Rodriguez-Portal JA, Budde K. Expert Opin Drug Saf 2014. 13:361–372. https://doi.org/10.1517/14740338.2014.888056 PMID:24517115

 

Immune responses of macrophages and dendritic cells regulated by mTOR signalling. Katholnig K, Linke M, Pham H, Hengstschläger M, Weichhart T. Biochem Soc Trans 2013. 41:927–933. https://doi.org/10.1042/BST20130032 PMID:23863158

 

Targeting the dysregulated mammalian target of rapamycin pathway in organ transplantation: killing 2 birds with 1 stone. Haidinger M, Werzowa J, Weichhart T, Säemann MD. Transplant Rev (Orlando) 2011. 25:145–153. https://doi.org/10.1016/j.trre.2010.11.001 PMID:21419611

 

The versatility of HDL: a crucial anti-inflammatory regulator. Säemann MD, Poglitsch M, Kopecky C, Haidinger M, Hörl WH, Weichhart T. Eur J Clin Invest 2010. 40:1131–1143. https://doi.org/10.1111/j.1365-2362.2010.02361.x PMID:20695882

 

The multifunctional role of mTOR in innate immunity: implications for transplant immunity. Säemann MD, Haidinger M, Hecking M, Hörl WH, Weichhart T. Am J Transplant 2009. 9:2655–2661. https://doi.org/10.1111/j.1600-6143.2009.02832.x PMID:19788500

 

The multiple facets of mTOR in immunity. Weichhart T, Säemann MD. Trends Immunol 2009. 30:218–226. https://doi.org/10.1016/j.it.2009.02.002 PMID:19362054

 

The PI3K/Akt/mTOR pathway in innate immune cells: emerging therapeutic applications. Weichhart T, Säemann MD. Ann Rheum Dis 2008. 67(Suppl 3):iii70–iii74. https://doi.org/10.1136/ard.2008.098459 PMID:19022819

 

Current concepts of molecular defence mechanisms operative during urinary tract infection. Weichhart T, Haidinger M, Hörl WH, Säemann MD. Eur J Clin Invest 2008. 38(Suppl 2):29–38. https://doi.org/10.1111/j.1365-2362.2008.02006.x PMID:18826479

 

Toll-like Rezeptoren und Integrine als Determinanten der Pathogenese des Harnwegsinfekts. Säemann MD, Hörl WH, Weichhart T. Nephro-News 2007. 3/07.

 

Die Bedeutung des unspezifischen Immunsystems für die Nierentransplantation. Säemann MD, Weichhart T. Nephro-News 2006. 3/06.

 

New insights into the pathogenesis of urinary tract infection. Säemann MD, Weichhart T. Dtsch Med Wochenschr 2005. 130:2031–2034. https://doi.org/10.1055/s-2005-872625 PMID:16143935

 

The multiple functions of Tamm-Horsfall protein in human health and disease: a mystery clears up. Weichhart T, Zlabinger GJ, Säemann MD. Wien Klin Wochenschr 2005. 117:316–322. https://doi.org/10.1007/s00508-005-0353-8 PMID:15989109

 

Tamm-Horsfall protein: a multilayered defence molecule against urinary tract infection. Säemann MD, Weichhart T, Hörl WH, Zlabinger GJ. Eur J Clin Invest 2005. 35:227–235. https://doi.org/10.1111/j.1365-2362.2005.01483.x PMID:15816991

 


Invited Editorials/Comments

Directions to overcome therapy resistance in cancer. Nussinov R, Weichhart T, Dlamini Z, Gibbons DL, Van Seuningen I, Konen J, Ju HQ. Trends Pharmacol Sci. 2024 May 16:S0165-6147(24)00093-2. doi: https://doi.org/10.1016/j.tips.2024.05.001. PMID:38760267

 

A fungal antigenic driver for Löfgren's syndrome sarcoidosis. Lim CX, Weichhart T. J Exp Med 2021. 218(10):e20211572 https://doi.org/10.1084/jem.20211572 PMID:34515726

New advances in the development of sarcoidosis models: A synopsis of a symposium sponsored by the Foundation for Sarcoidosis Research. Sellares J, Strambu I, Crouser ED, Freudenberg MA, Gulati M, Hart S, Herzog E, Kolb M, Weichhart T, Drake WP, Spitzer G, Singh N, Culver DA. Sarcoidosis Vasc Diffuse Lung Dis 2018. 35 (1) 2-4. http://www.mattioli1885journals.com/index.php/sarcoidosis/article/view/7032

 

TORching a semaphore for alternative macrophage activation. Wilson JL, Weichhart T. Nat Immunol 2018. 19:512-514 https://doi.org/10.1038/s41590-018-0117-z PMID:29777214

 

HDL cholesterol efflux capacity and cardiovascular events. Kopecky C, Weichhart T, Säemann MD. N Engl J Med 2015. 372:1869–1872. https://doi.org/10.1056/NEJMc1503139 PMID:25946299

 

Sirolimus and kidney transplantation: unraveling an inflammatory affair. Weichhart T, Säemann MD. Am J Transplant 2010. 10:2569–2570. https://doi.org/10.1111/j.1600-6143.2010.03306.x PMID:21114639

 

T helper cell differentiation: understanding the needs of hierarchy. Weichhart T, Säemann MD. Immunity 2010. 32:727–729. https://doi.org/10.1016/j.immuni.2010.06.008 PMID:20620936

 

Uncovering host defences in the urinary tract: cathelicidin and beyond. Säemann MD, Hörl WH, Weichhart T. Nephrol Dial Transplant 2007. 22:347–349. https://doi.org/10.1093/ndt/gfl590 PMID:17035368

 


Books, book chapters

Lysis gradient centrifugation: a flexible method for the isolation of nuclei from primary cells. Katholnig K, Poglitsch M, Hengstschläger M, Weichhart T. Methods Mol Biol 2015. 1228:15–23. https://doi.org/10.1007/978-1-4939-1680-1_2 PMID:25311118

 

Mammalian target of rapamycin: a signaling kinase for every aspect of cellular life. Weichhart T. Methods Mol Biol 2012. 821:1–14. https://doi.org/10.1007/978-1-61779-430-8_1 PMID:22125056

 

Editor of “mTOR: Methods and Protocols”. Methods in Molecular Biology, Humana Press, 2012. https://link.springer.com/book/10.1007/978-1-61779-430-8