Publications

Selected Literature

Duodenal macrophages control dietary iron absorption via local degradation of transferrin. Sukhbaatar N, Schöller M, Fritsch SD, Linke M, Horer S, Träger M, Mazic M, Forisch S, Gonzales K, Kahler JP, Binder C, Lassnig C, Strobl B, Mueller M, Scheiber-Mojdehkar B, Gundacker C, Dabsch S, Kain R, Hengstschläger M, Verhelst S, Weiss G, Theurl I, Weichhart T. Blood 2023 Apr 5:blood.2022016632. https://doi.org/10.1182/blood.2022016632 PMID:37018657

Linke M, Pham HT, Katholnig K, Schnöller T, Miller A, Demel F, Schütz B, Rosner M, Kovacic B, Sukhbaatar N, Niederreiter B, Blüml S, Kuess P, Sexl V, Müller M, Mikula M, Weckwerth W, Haschemi A, Susani M, Hengstschläger M, Gambello MJ, Weichhart T.
Chronic signaling via the metabolic checkpoint kinase mTORC1 induces macrophage granuloma formation and marks sarcoidosis progression. Nat Immunol 2017. 18:293–302. https://doi.org/10.1038/ni.3655 PMID:28092373

Wilson JL, Nägele T, Linke M, Demel F, Fritsch SD, Mayr HK, Cai Z, Katholnig K, Sun X, Fragner L, Miller A, Haschemi A, Popa A, Bergthaler A, Hengstschläger M, Weichhart T, Weckwerth W. Cell Rep 2020. Feb 4;30(5):1542-1552.e7. Inverse Data-Driven Modeling and Multiomics Analysis Reveals Phgdh as a Metabolic Checkpoint of Macrophage Polarization and Proliferation. https://doi.org/10.1016/j.celrep.2020.01.011 PMID:32023468

Wilson JL, Mayr HK, Weichhart T.

Metabolic Programming of Macrophages: Implications in the Pathogenesis of Granulomatous Disease. Front Immunol 2019. 10:2265. https://doi.org/10.3389/fimmu.2019.02265 PMID:31681260

Katholnig K, Schütz B, Fritsch SD, Schörghofer D, Linke M, Sukhbaatar N, Matschinger JM, Unterleuthner D, Hirtl M, Lang M, Herac M, Spittler A, Bergthaler A, Schabbauer G, Bergmann M, Dolznig H, Hengstschläger M, Magnuson MA, Mikula M, Weichhart T.
Inactivation of mTORC2 in macrophages is a signature of colorectal cancer that promotes tumorigenesis. JCI Insight 2019. 14(20). pii: 124164. https://doi.org/10.1172/jci.insight.124164 PMID:1619583

Weichhart T, Hengstschläger M, Linke M.
Regulation of innate immune cell function by mTOR. Nat Rev Immunol 2015. 15:599–614. https://doi.org/10.1038/nri3901 PMID:26403194

Peer reviewed original publications

Krausgruber T, Redl A, Barreca D, Doberer K, Romanovskaia D, Dobnikar L, Guarini M, Unterluggauer L, Kleissl L, Atzmüller D, Mayerhofer C, Kopf A, Saluzzo S, Lim CX, Rexie P, Weichhart T, Bock C, Stary G. Immunity 2023 Feb 6:S1074-7613(23)00024-9. Single-cell and spatial transcriptomics reveal aberrant lymphoid developmental programs driving granuloma formation. https://doi.org/10.1016/j.immuni.2023.01.014 PMID:36750099

Pototschnig I, Feiler U, Diwoky C, Vesely PW, Rauchenwald T, Paar M, Bakiri L, Pajed L, Hofer P, Kashofer K, Sukhbaatar N, Schoiswohl G, Weichhart T, Hoefler G, Bock C, Pichler M, Wagner EF, Zechner R, Schweiger M. J Cachexia Sarcopenia Muscle 2022 Nov 9. Interleukin-6 initiates muscle- and adipose tissue wasting in a novel C57BL/6 model of cancer-associated cachexia. https://doi.org/10.1002/jcsm.13109 PMID:36351437

Gonçales RA, Bastos HN, Duarte-Oliveira C, Antunes D, Sokhatska O, Jacob M, Rolo R, Campos CF, Sasaki SD, Donato A, Mapelli SN, Costa S, Moura CS, Delgado L, Morais A, Torrado E, van de Veerdonk FL, Weichhart T, Lambris JD, Silvestre R, Garlanda C, Mantovani A, Cunha C, Carvalho A. Am J Respir Crit Care Med 2022 Jun 29. PTX3 Inhibits Complement-Driven Macrophage Activation to Restrain Granuloma Formation in Sarcoidosis. https://doi.org/10.1164/rccm.202112-2771OC PMID:35767663

Sipka AS, Chandler TL, Weichhart T, Schuberth HJ, Mann S. Sci Rep 2022 Sep 5;12(1):15084. Inhibition of mTOR in bovine monocyte derived macrophages and dendritic cells provides a potential mechanism for postpartum immune dysfunction in dairy cows. https://doi.org/10.1038/s41598-022-19295-1 PMID:36064574

Sipka A, Weichhart T, Mann S. Vet Immunol Immunopathol. 2022 Jul;249:110441. Pharmacological inhibition of the mTOR pathway alters phenotype and cytokine expression in bovine monocyte-derived dendritic cells. https://doi.org/10.1016/j.vetimm.2022.110441 PMID:35597229

Kraaijvanger R, Seldenrijk K, Beijer E, Damen J, Wilson JL, Weichhart T, Grutters JC, Veltkamp M. Cells 2021 Dec 15;10(12):3545. Activation of Downstream mTORC1 Target Ribosomal Protein S6 Kinase (S6K) Can Be Found in a Subgroup of Dutch Patients with Granulomatous Pulmonary Disease. https://doi.org/110.3390/cells10123545 PMID:34944053

Braun C, Katholnig K, Kaltenecker C, Linke M, Sukhbaatar N, Hengstschläger M, Weichhart T. Cell Stress 2021 Nov 23;5(12):176-182. p38 regulates the tumor suppressor PDCD4 via the TSC-mTORC1 pathway. https://doi.org/10.15698/cst2021.12.260 PMID:34917890

Zhu C, Boucheron N, Müller AC, Májek P, Claudel T, Halilbasic E, Baazim H, Lercher A, Viczenczova C, Hainberger D, Preglej T, Sandner L, Alteneder M, Gülich AF, Khan M, Hamminger P, Remetic J, Ohradanova-Repic A, Schatzlmaier P, Donner C, Fuchs CD, Stojakovic T, Scharnagl H, Sakaguchi S, Weichhart T, Bergthaler A, Stockinger H, Ellmeier W, Trauner M. J Hepatol 2021. Jul 6. 24-NorUrsodeoxycholic acid reshapes immunometabolism in CD8 + T-cells and alleviates hepatic inflammation. https://doi.org/10.1016/j.jhep.2021.06.036 PMID:34242699

Pizzini A, Bacher H, Aichner M, Franchi A, Watzinger K, Tancevski I, Sonnweber T, Mosheimer-Feistritzer B, Duftner C, Zelger B, Pallua J, Sprung S, Weichhart T, Zelger B, Weiss G, Löffler-Ragg J. Respir Med 2021 Jan 5;177:106294. High expression of mTOR signaling in granulomatous lesions is not predictive for the clinical course of sarcoidosis. https://doi.org/10.1016/j.rmed.2020.106294 PMID:33485108

Brunner JS, Vogel A, Lercher A, Caldera M, Korosec A, Pühringer M, Hofmann M, Hajto A, Kieler M, Garrido LQ, Kerndl M, Kuttke M, Mesteri I, Górna MW, Kulik M, Dominiak PM, Brandon AE, Estevez E, Egan CL, Gruber F, Schweiger M, Menche J, Bergthaler A, Weichhart T, Klavins K, Febbraio MA, Sharif O, Schabbauer G. Nat Metabolism 2020. Nov 16. The PI3K pathway preserves metabolic health through MARCO-dependent lipid uptake by adipose tissue macrophages. https://doi.org/10.1038/s42255-020-00311-5 PMID:33199895

Wilson JL, Nägele T, Linke M, Demel F, Fritsch SD, Mayr HK, Cai Z, Katholnig K, Sun X, Fragner L, Miller A, Haschemi A, Popa A, Bergthaler A, Hengstschläger M, Weichhart T, Weckwerth W. Cell Rep 2020. Feb 4;30(5):1542-1552.e7. Inverse Data-Driven Modeling and Multiomics Analysis Reveals Phgdh as a Metabolic Checkpoint of Macrophage Polarization and Proliferation. https://doi.org/10.1016/j.celrep.2020.01.011 PMID:32023468

Brunner JS, Vulliard L, Hofmann M, Kieler M, Lercher A, Vogel A, Russier M, Brüggenthies JB, Kerndl M, Saferding V, Niederreiter B, Junza A, Frauenstein A, Scholtysek C, Mikami Y, Klavins K, Krönke G, Bergthaler A, O'Shea JJ, Weichhart T, Meissner F, Smolen JS, Cheng P, Yanes O, Menche J, Murray PJ, Sharif O, Blüml S, Schabbauer G. Nat Commun 2020. Jan 22;11(1):431. Environmental arginine controls multinuclear giant cell metabolism and formation. https://doi.org/10.1038/s41467-020-14285-1 PMID:31969567

Menzl I, Zhang T, Berger-Becvar A, Grausenburger R, Heller G, Prchal-Murphy M, Edlinger L, Knab VM, Uras IZ, Grundschober E, Bauer K, Roth M, Skucha A, Liu Y, Hatcher JM, Liang Y, Kwiatkowski NP, Fux D, Hoelbl-Kovacic A, Kubicek S, Melo JV, Valent P, Weichhart T, Grebien F, Zuber J, Gray NS, Sexl V. A kinase-independent role for CDK8 in BCR-ABL1+ leukemia. Nat Commun 2019. 10:4741. https://doi.org/10.1038/s41467-019-12656-x PMID:31628323

Katholnig K, Schütz B, Fritsch SD, Schörghofer D, Linke M, Sukhbaatar N, Matschinger JM, Unterleuthner D, Hirtl M, Lang M, Herac M, Spittler A, Bergthaler A, Schabbauer G, Bergmann M, Dolznig H, Hengstschläger M, Magnuson MA, Mikula M, Weichhart T. Inactivation of mTORC2 in macrophages is a signature of colorectal cancer that promotes tumorigenesis. JCI Insight. 2019.14(20). pii: 124164. https://doi.org/10.1172/jci.insight.124164 PMID:1619583

Calender A, Lim CX, Weichhart T, Buisson A, Besnard V, Rollat-Farnier PA, Bardel C, Roy P, Cottin V, Devouassoux G, Finat A, Pinson S, Lebecque S, Nunes H, Israel-Biet D, Bentaher A, Valeyre D, Pacheco Y; in the frame of GSF (Group Sarcoidosis France). Exome sequencing and pathogenicity-network analysis of 5 French families implicate mTOR signalling and autophagy in familial sarcoidosis. Eur Respir J. 2019. Apr 25. pii: 1900430. https://doi.org/10.1183/13993003.00430-2019 PMID:31023854

Karonitsch T, Kandasamy RK, Kartnig F, Herdy B, Dalwigk K, Niederreiter B, Holinka J, Sevelda F, Windhager R, Bilban M, Weichhart T, Säemann M, Pap T, Steiner G, Smolen JS, Kiener HP, Superti-Furga G. mTOR Senses Environmental Cues to Shape the Fibroblast-like Synoviocyte Response to Inflammation. Cell Rep 2018. 23:2157-2167. https://doi.org/10.1016/j.celrep.2018.04.044 PMID:29768212

Calender A, Rollat Farnier PA, Buisson A, Pinson S, Bentaher A, Lebecque S, Corvol H, Abou Taam R, Houdouin V, Bardel C, Roy P, Devouassoux G, Cottin V, Seve P, Bernaudin JF, Lim CX, Weichhart T, Valeyre D, Pacheco Y, Clement A, Nathan N; in the frame of GSF (Groupe Sarcoïdose France). Whole exome sequencing in three families segregating a pediatric case of sarcoidosis. BMC Med Genomics 2018. 11:23. https://doi.org/10.1186/s12920-018-0338-x PMID:29510755

Kopecky C, Michlits G, Säemann MD, Weichhart T. Pro- versus Anti-inflammatory Actions of HDLs in Innate Immunity. Cell Metab 2017. 26:2-3. https://doi.org/10.1016/j.cmet.2017.04.007 PMID:28648980

Vijayan V, Srinu T, Karnati S, Garikapati V, Linke M, Kamalyan L, Mali SR, Sudan K, Kollas A, Schmid T, Schulz S, Spengler B, Weichhart T, Immenschuh S, Baumgart-Vogt E. A New Immunomodulatory Role for Peroxisomes in Macrophages Activated by the TLR4 Ligand Lipopolysaccharide. J Immunol 2017. 198:2414–2425. https://doi.org/10.4049/jimmunol.1601596 PMID:28179495

Kopecky C, Ebtehaj S, Genser B, Drechsler C, Krane V, Antlanger M, Kovarik JJ, Kaltenecker CC, Parvizi M, Wanner C, Weichhart T, Säemann MD, Tietge UJ. HDL Cholesterol Efflux Does Not Predict Cardiovascular Risk in Hemodialysis Patients. J Am Soc Nephrol 2017. 28:769–775. https://doi.org/10.1681/ASN.2016030262 PMID:27612996

Linke M, Pham HT, Katholnig K, Schnöller T, Miller A, Demel F, Schütz B, Rosner M, Kovacic B, Sukhbaatar N, Niederreiter B, Blüml S, Kuess P, Sexl V, Müller M, Mikula M, Weckwerth W, Haschemi A, Susani M, Hengstschläger M, Gambello MJ, Weichhart T. Chronic signaling via the metabolic checkpoint kinase mTORC1 induces macrophage granuloma formation and marks sarcoidosis progression. Nat Immunol 2017. 18:293–302. https://doi.org/10.1038/ni.3655 PMID:28092373

Genser B, Fischer JE, Figueiredo CA, Alcântara-Neves N, Barreto ML, Cooper PJ, Amorim LD, Saemann MD, Weichhart T, Rodrigues LC. Applied immuno-epidemiological research: an approach for integrating existing knowledge into the statistical analysis of multiple immune markers. BMC Immunol 2016. 17:11. https://doi.org/10.1186/s12865-016-0149-9 PMID:27206492

Üstün S, Lassnig C, Preitschopf A, Mikula M, Müller M, Hengstschläger M, Weichhart T. 2015. Effects of the mTOR inhibitor everolimus and the PI3K/mTOR inhibitor NVP-BEZ235 in murine acute lung injury models. Transpl Immunol 2015. 33:45–50. https://doi.org/10.1016/j.trim.2015.06.001 PMID:26073719

Kopecky C, Genser B, Drechsler C, Krane V, Kaltenecker CC, Hengstschläger M, März W, Wanner C, Säemann MD, Weichhart T. Quantification of HDL proteins, cardiac events, and mortality in patients with type 2 diabetes on hemodialysis. Clin J Am Soc Nephrol 2015. 10:224–231. https://doi.org/10.2215/CJN.06560714 PMID:25424990

Preitschopf A, Li K, Schörghofer D, Kinslechner K, Schütz B, Thi Thanh Pham H, Rosner M, Joo GJ, Röhrl C, Weichhart T, Stangl H, Lubec G, Hengstschläger M, Mikula M. mTORC1 is essential for early steps during Schwann cell differentiation of amniotic fluid stem cells and regulates lipogenic gene expression. PLoS One 2014. 9:e107004. https://doi.org/10.1371/journal.pone.0107004 PMID:25221943

Kopecky C, Haidinger M, Birner-Grünberger R, Darnhofer B, Kaltenecker CC, Marsche G, Holzer M, Weichhart T, Antlanger M, Kovarik JJ, Werzowa J, Hecking M, Säemann MD. Restoration of Renal Function Does Not Correct Impairment of Uremic HDL Properties. J Am Soc Nephrol 2015. 26:565-75.https://doi.org/10.1681/ASN.2013111219 PMID:25071090

Fruhwürth S, Krieger S, Winter K, Rosner M, Mikula M, Weichhart T, Bittman R, Hengstschläger M, Stangl H. Inhibition of mTOR Down-regulates Scavenger Receptor, Class B, Type I (SR-BI) Expression, Reduces Endothelial Cell Migration and Impairs Nitric Oxide Production. Biochim Biophys Acta 2014. 1841:944-53. https://doi.org/10.1016/j.bbalip.2014.03.014 PMID:24713582

Haidinger M, Werzowa J, Kain R, Antlanger M, Hecking M, Pfaffenberger S, Mascherbauer J, Gremmel T, Gilbertson JA, Rowczenio D, Weichhart T, Kopecky C, Hörl WH, Hawkins PN, Säemann MD. Hereditary amyloidosis caused by R554L fibrinogen Aα-chain mutation in a Spanish family and review of the literature. Amyloid 2013. 20:72–79. https://doi.org/10.3109/13506129.2013.781998 PMID:23551149

Katholnig K, Kaltenecker CC, Hayakawa H, Rosner M, Lassnig C, Zlabinger GJ, Gaestel M, Müller M, Hengstschläger M, Hörl WH, Park JM, Säemann MD, Weichhart T. p38α senses environmental stress to control innate immune responses via mTOR. J Immunol 2013. 190:1519–1527. https://doi.org/10.4049/jimmunol.1202683 PMID:23315073

Laimer D, Dolznig H, Kollmann K, Vesely PW, Schlederer M, Merkel O, Schiefer AI, Hassler MR, Heider S, Amenitsch L, Thallinger C, Staber PB, Simonitsch-Klupp I, Artaker M, Lagger S, Turner SD, Pileri S, Piccaluga PP, Valent P, Messana K, Landra I, Weichhart T, Knapp S, Shehata M, Todaro M, Sexl V, Höfler G, Piva R, Medico E, Ruggeri BA, Cheng M, Eferl R, Egger G, Penninger JM, Jaeger U, Moriggl R, Inghirami G, Kenner L. PDGFR blockade is a rational and effective therapy for NPM-ALK-driven lymphomas. Nat Med 2012. 18:1699–1704. https://doi.org/10.1038/nm.2966 PMID:23064464

Hecking M, Antlanger M, Winnicki W, Reiter T, Werzowa J, Haidinger M, Weichhart T, Polaschegg HD, Josten P, Exner I, Lorenz-Turnheim K, Eigner M, Paul G, Klauser-Braun R, Hörl WH, Sunder-Plassmann G, Säemann MD. Blood volume-monitored regulation of ultrafiltration in fluid-overloaded hemodialysis patients: study protocol for a randomized controlled trial. Trials 2012. 13:79. https://doi.org/10.1186/1745-6215-13-79 PMID:22682149

Poglitsch M, Weichhart T, Hecking M, Werzowa J, Katholnig K, Antlanger M, Krmpotic A, Jonjic S, Hörl WH, Zlabinger GJ, Puchhammer E, Säemann MD. CMV late phase-induced mTOR activation is essential for efficient virus replication in polarized human macrophages. Am J Transplant 2012. 12:1458–1468. https://doi.org/10.1111/j.1600-6143.2012.04002.x PMID:22390651

Weichhart T, Kopecky C, Kubicek M, Haidinger M, Döller D, Katholnig K, Suarna C, Eller P, Tölle M, Gerner C, Zlabinger GJ, van der Giet M, Hörl WH, Stocker R, Säemann MD. Serum amyloid A in uremic HDL promotes inflammation. J Am Soc Nephrol 2012. 23:934–947. https://doi.org/10.1681/ASN.2011070668 PMID:22282592

Atamaniuk J, Kopecky C, Skoupy S, Säemann MD, Weichhart T. Apoptotic cell-free DNA promotes inflammation in haemodialysis patients. Nephrol Dial Transplant 2012. 27:902–905. https://doi.org/10.1093/ndt/gfr695 PMID:22167588

Poglitsch M, Katholnig K, Säemann MD, Weichhart T. Rapid isolation of nuclei from living immune cells by a single centrifugation through a multifunctional lysis gradient. J Immunol Methods 2011. 373:167–173. https://doi.org/10.1016/j.jim.2011.08.012 PMID:21889513

Weichhart T, Haidinger M, Katholnig K, Kopecky C, Poglitsch M, Lassnig C, Rosner M, Zlabinger GJ, Hengstschläger M, Müller M, Hörl WH, Säemann MD. Inhibition of mTOR blocks the anti-inflammatory effects of glucocorticoids in myeloid immune cells. Blood 2011. 117:4273–4283. https://doi.org/10.1182/blood-2010-09-310888 PMID:21368289

Haidinger M, Werzowa J, Voigt HC, Pleiner J, Stemer G, Hecking M, Döller D, Hörl WH, Weichhart T, Säemann MD. A randomized, placebo-controlled, double-blind, prospective trial to evaluate the effect of vildagliptin in new-onset diabetes mellitus after kidney transplantation. Trials 2010. 11:91. https://doi.org/10.1186/1745-6215-11-91 PMID:20925938

Haidinger M, Poglitsch M, Geyeregger R, Kasturi S, Zeyda M, Zlabinger GJ, Pulendran B, Hörl WH, Säemann MD, Weichhart T. A versatile role of mammalian target of rapamycin in human dendritic cell function and differentiation. J Immunol 2010. 185:3919–3931. https://doi.org/10.4049/jimmunol.1000296 PMID:20805416

Wahrmann M, Haidinger M, Körmöczi GF, Weichhart T, Säemann MD, Geyeregger R, Kikić Z, Prikoszovich T, Drach J, Böhmig GA. Effect of the proteasome inhibitor bortezomib on humoral immunity in two presensitized renal transplant candidates. Transplantation 2010. 89:1385–1390. https://doi.org/10.1097/TP.0b013e3181d9e1c0 PMID:20335829

Kiefer FW, Zeyda M, Gollinger K, Pfau B, Neuhofer A, Weichhart T, Säemann MD, Geyeregger R, Schlederer M, Kenner L, Stulnig TM. Neutralization of osteopontin inhibits obesity-induced inflammation and insulin resistance. Diabetes 2010. 59:935–946. https://doi.org/10.2337/db09-0404 PMID:20107108

Haidinger M, Hecking M, Weichhart T, Poglitsch M, Enkner W, Vonbank K, Prayer D, Geusau A, Oberbauer R, Zlabinger GJ, Soleiman A, Hörl WH, Säemann MD. Sirolimus in renal transplant recipients with tuberous sclerosis complex: clinical effectiveness and implications for innate immunity. Transpl Int 2010. 23:777–785. https://doi.org/10.1111/j.1432-2277.2009.01041.x PMID:20070623

Weichhart T, Brandt O, Lassnig C, Müller M, Hörl WH, Stingl G, Säemann MD. The anti-inflammatory potency of dexamethasone is determined by the route of application in vivo. Immunol Lett 2010. 129:50–52. https://doi.org/10.1016/j.imlet.2009.12.025 PMID:20060857

Haidinger M, Hecking M, Memarsadeghi M, Weichhart T, Werzowa J, Hörl WH, Säemann MD. Late onset Pneumocystis pneumonia in renal transplantation after long-term immunosuppression with belatacept. Transpl Infect Dis 2009. 11:171–174. https://doi.org/10.1111/j.1399-3062.2009.00366.x PMID:19210692

Weichhart T, Costantino G, Poglitsch M, Rosner M, Zeyda M, Stuhlmeier KM, Kolbe T, Stulnig TM, Hörl WH, Hengstschläger M, Müller M, Säemann MD. The TSC-mTOR signaling pathway regulates the innate inflammatory response. Immunity 2008. 29:565–577. https://doi.org/10.1016/j.immuni.2008.08.012 PMID:18848473

Weichhart T, Werzowa J, Hörl WH, Säemann MD. Biological action of rapamycin in renal transplantation. Am J Kidney Dis 2008. 51:531, author reply 531–532. https://doi.org/10.1053/j.ajkd.2007.09.027 PMID:18295073

Kiefer FW, Zeyda M, Todoric J, Huber J, Geyeregger R, Weichhart T, Aszmann O, Ludvik B, Silberhumer GR, Prager G, Stulnig TM. Osteopontin expression in human and murine obesity: extensive local up-regulation in adipose tissue but minimal systemic alterations. Endocrinology 2008. 149:1350–1357. https://doi.org/10.1210/en.2007-1312 PMID:18048491

Pfistershammer K, Klauser C, Leitner J, Stöckl J, Majdic O, Weichhart T, Sobanov Y, Bochkov V, Säemann M, Zlabinger G, Steinberger P. Identification of the scavenger receptors SREC-I, Cla-1 (SR-BI), and SR-AI as cellular receptors for Tamm-Horsfall protein. J Leukoc Biol 2008. 83:131–138. https://doi.org/10.1189/jlb.0407231 PMID:17928461

Haidinger M, Geyeregger R, Poglitsch M, Weichhart T, Zeyda M, Vodenik B, Stulnig TM, Böhmig GA, Hörl WH, Säemann MD. Antithymocyte globulin impairs T-cell/antigen-presenting cell interaction: disruption of immunological synapse and conjugate formation. Transplantation 2007.84:117–121. https://doi.org/10.1097/01.tp.0000266677.45428.80 PMID:17627247

Bobacz K, Sunk IG, Amoyo L, Akira S, Weichhart T, Säemann MD, Smolen JS. Toll-like receptors and chondrocytes: the LPS induced decrease in cartilage mytrix synthesis is dependent on the presence of Toll-like receptor-4 and is antagonized by bone morphogenetic protein-7. Arthritis Rheum 2007. 56:1880–1893. https://doi.org/10.1002/art.22637 PMID:17530716

Huber J, Löffler M, Bilban M, Reimers M, Kadl A, Todoric J, Zeyda M, Geyeregger R, Schreiner M, Weichhart T, Leitinger N, Waldhäusl W, Stulnig TM. Prevention of high-fat diet-induced adipose tissue remodeling in obese diabetic mice by n-3 polyunsaturated fatty acids. Int J Obes 2007. 31:1004–1013. https://doi.org/10.1038/sj.ijo.0803511 PMID:17130847

Zeyda M, Geyeregger R, Poglitsch M, Weichhart T, Zlabinger GJ, Koyasu S, Hörl WH, Stulnig TM, Watschinger B, Säemann MD. Impairment of T cell interactions with antigen-presenting cells by immunosuppressive drugs reveals involvement of calcineurin and NF-kappaB in immunological synapse formation. J Leukoc Biol 2007. 81:319–327. https://doi.org/10.1189/jlb.0606378 PMID:17038582

Säemann MD, Weichhart T, Zeyda M, Staffler G, Schunn M, Stuhlmeier KM, Sobanov Y, Stulnig TM, Akira S, von Gabain A, von Ahsen U, Hörl WH, Zlabinger GJ. Tamm-Horsfall glycoprotein links innate immune cell activation with adaptive immunity via a Toll-like receptor-4-dependent mechanism. J Clin Invest 2005. 115:468–475. https://doi.org/10.1172/JCI200522720 PMID:15650774

Weichhart T, Horky M, Söllner J, Gangl S, Henics T, Nagy E, Meinke A, von Gabain A, Fraser CM, Gill SR, Hafner M, von Ahsen U. Functional selection of vaccine candidate peptides from Staphylococcus aureus whole-genome expression libraries in vitro. Infect Immun 2003. 71:4633–4641. https://doi.org/10.1128/IAI.71.8.4633-4641.2003 PMID:12874343

Reviews

Braun C, Weichhart T. mTOR-dependent immunometabolism as Achilles' heel of anticancer therapy. Eur J Immunol 2021 Dec;51(12):3161-3175. https://doi.org/10.1002/eji.202149270 PMID:34648202

Calender A, Weichhart T, Valeyre D, Pacheco Y. Current Insights in Genetics of Sarcoidosis: Functional and Clinical Impacts. J Clin Med 2020. 9(8):E2633. https://doi.org/10.3390/jcm9082633 PMID:32823753

Fritsch SD, Weichhart T. Metabolic and immunologic control of intestinal cell function by mTOR. Int Immunol 2020. 32(7):455-465. https://doi.org/10.1093/intimm/dxaa015 PMID:32140726

Pacheco Y, Lim CX, Weichhart T, Valeyre D, Bentaher A, Calender A. Sarcoidosis and the mTOR, Rac1, and Autophagy Triad. Trends Immunol 2020. 41(4):286-299. https://doi.org/10.1016/j.it.2020.01.007 PMID:32122794

Wilson JL, Mayr HK, Weichhart T. Metabolic Programming of Macrophages: Implications in the Pathogenesis of Granulomatous Disease. Front Immunol. 2019. 10:2265. https://doi.org/10.3389/fimmu.2019.02265 PMID:31681260

Sukhbaatar N, Weichhart T. Iron Regulation: Macrophages in Control. Pharmaceuticals (Basel) 2018. 14;11(4). https://doi.org/10.3390/ph11040137 PMID:30558109

Weichhart T. mTOR as Regulator of Lifespan, Aging, and Cellular Senescence: A Mini-Review. Gerontology 2018. 64:127-134. https://doi.org/10.1159/000484629 PMID:29190625

Linke M, Fritsch SD, Sukhbaatar N, Hengstschläger M, Weichhart T. mTORC1 and mTORC2 as regulators of cell metabolism in immunity. FEBS Lett 2017. 591:3089–3103. https://doi.org/10.1002/1873-3468.12711 PMID:28600802

Fritsch S, Weichhart T. Effects of interferons and viruses on metabolism, Frontiers Immunol 2016. 7:630. https://doi.org/10.3389/fimmu.2016.00630 PMID:28066439

Sukhbaatar N, Hengstschläger M, Weichhart T. mTOR-mediated regulation of dendritic cell differentiation and function, Trends Immunol 2016. 37:778-789. https://doi.org/10.1016/j.it.2016.08.009 PMID:27614799

Weichhart T, Hengstschläger M, Linke M. Regulation of innate immune cell function by mTOR. Nat Rev Immunol 2015. 15:599–614. https://doi.org/10.1038/nri3901 PMID:26403194

Duran I, Goebell PJ, Papazisis K, Ravaud A, Weichhart T, Rodriguez-Portal JA, Budde K. Drug-induced pneumonitis in cancer patients treated with mTOR inhibitors: management and insights into possible mechanisms. Expert Opin Drug Saf 2014. 13:361–372. https://doi.org/10.1517/14740338.2014.888056 PMID:24517115

Katholnig K, Linke M, Pham H, Hengstschläger M, Weichhart T. Immune responses of macrophages and dendritic cells regulated by mTOR signalling. Biochem Soc Trans 2013. 41:927–933. https://doi.org/10.1042/BST20130032 PMID:23863158

Haidinger M, Werzowa J, Weichhart T, Säemann MD. Targeting the dysregulated mammalian target of rapamycin pathway in organ transplantation: killing 2 birds with 1 stone. Transplant Rev (Orlando) 2011. 25:145–153. https://doi.org/10.1016/j.trre.2010.11.001 PMID:21419611

Säemann MD, Poglitsch M, Kopecky C, Haidinger M, Hörl WH, Weichhart T. The versatility of HDL: a crucial anti-inflammatory regulator. Eur J Clin Invest 2010. 40:1131–1143. https://doi.org/10.1111/j.1365-2362.2010.02361.x PMID:20695882

Säemann MD, Haidinger M, Hecking M, Hörl WH, Weichhart T. The multifunctional role of mTOR in innate immunity: implications for transplant immunity. Am J Transplant 2009. 9:2655–2661. https://doi.org/10.1111/j.1600-6143.2009.02832.x PMID:19788500

Weichhart T, Säemann MD. The multiple facets of mTOR in immunity. Trends Immunol 2009. 30:218–226. https://doi.org/10.1016/j.it.2009.02.002 PMID:19362054

Weichhart T, Säemann MD. The PI3K/Akt/mTOR pathway in innate immune cells: emerging therapeutic applications. Ann Rheum Dis 2008. 67(Suppl 3):iii70–iii74. https://doi.org/10.1136/ard.2008.098459 PMID:19022819

Weichhart T, Haidinger M, Hörl WH, Säemann MD. Current concepts of molecular defence mechanisms operative during urinary tract infection. Eur J Clin Invest 2008. 38(Suppl 2):29–38. https://doi.org/10.1111/j.1365-2362.2008.02006.x PMID:18826479

Säemann MD, Hörl WH, Weichhart T. Toll-like Rezeptoren und Integrine als Determinanten der Pathogenese des Harnwegsinfekts, Nephro-News 2007. 3/07.

Säemann MD, Weichhart T. Die Bedeutung des unspezifischen Immunsystems für die Nierentransplantation, Nephro-News 2006. 3/06.

Säemann MD, Weichhart T. New insights into the pathogenesis of urinary tract infection. Dtsch Med Wochenschr 2005. 130:2031–2034. https://doi.org/10.1055/s-2005-872625 PMID:16143935

Weichhart T, Zlabinger GJ, Säemann MD. The multiple functions of Tamm-Horsfall protein in human health and disease: a mystery clears up. Wien Klin Wochenschr 2005. 117:316–322. https://doi.org/10.1007/s00508-005-0353-8 PMID:15989109

Säemann MD, Weichhart T, Hörl WH, Zlabinger GJ. Tamm-Horsfall protein: a multilayered defence molecule against urinary tract infection. Eur J Clin Invest 2005. 35:227–235. https://doi.org/10.1111/j.1365-2362.2005.01483.x PMID:15816991

Invited Editorials/Comments

Lim CX, Weichhart T. A fungal antigenic driver for Löfgren's syndrome sarcoidosis. J Exp Med 2021. 218(10):e20211572 https://doi.org/10.1084/jem.20211572 PMID:34515726

Sellares J, Strambu I, Crouser ED, Freudenberg MA, Gulati M, Hart S, Herzog E, Kolb M, Weichhart T, Drake WP, Spitzer G, Singh N, Culver DA. New advances in the development of sarcoidosis models: A synopsis of a symposium sponsored by the Foundation for Sarcoidosis Research. Sarcoidosis Vasc Diffuse Lung Dis 2018. 35 (1) 2-4. http://www.mattioli1885journals.com/index.php/sarcoidosis/article/view/7032

Wilson JL, Weichhart T. TORching a semaphore for alternative macrophage activation. Nat Immunol 2018. 19:512-514 https://doi.org/10.1038/s41590-018-0117-z PMID:29777214

Kopecky C, Weichhart T, Säemann MD. HDL cholesterol efflux capacity and cardiovascular events. N Engl J Med 2015. 372:1869–1872. https://doi.org/10.1056/NEJMc1503139 PMID:25946299

Weichhart T, Säemann MD. Sirolimus and kidney transplantation: unraveling an inflammatory affair. Am J Transplant 2010. 10:2569–2570. https://doi.org/10.1111/j.1600-6143.2010.03306.x PMID:21114639

Weichhart T, Säemann MD. T helper cell differentiation: understanding the needs of hierarchy. Immunity 2010. 32:727–729. https://doi.org/10.1016/j.immuni.2010.06.008 PMID:20620936

Säemann MD, Hörl WH, Weichhart T. Uncovering host defences in the urinary tract: cathelicidin and beyond. Nephrol Dial Transplant 2007. 22:347–349. https://doi.org/10.1093/ndt/gfl590 PMID:17035368

Books, book chapters

Katholnig K, Poglitsch M, Hengstschläger M, Weichhart T. Lysis gradient centrifugation: a flexible method for the isolation of nuclei from primary cells. Methods Mol Biol 2015. 1228:15–23. https://doi.org/10.1007/978-1-4939-1680-1_2 PMID:25311118

Weichhart T. Mammalian target of rapamycin: a signaling kinase for every aspect of cellular life. Methods Mol Biol 2012. 821:1–14. https://doi.org/10.1007/978-1-61779-430-8_1 PMID:22125056

Editor of “mTOR: Methods and Protocols”, Methods in Molecular Biology, Humana Press, 2012. https://link.springer.com/book/10.1007/978-1-61779-430-8