New study from Jayne and Moni from the lab together with Thomas Nägele and Wolfram Weckwerth! We show that that Tsc2 influences the metabolome of macrophages. Inverse data-driven modeling and multiomics data reveal that Phgdh is an Tsc2-mTORC1-dependent metabolic checkpoint of macrophage proliferation and polarization. Phgdh is required for the expression of key anti-inflammatory molecules and M2 proliferation. Study published in Cell Reports (02/2020)
New study from Karl, Birgit and Stephi from the lab! We find mTORC2 activity mainly in macrophages but not tumor cells in colorectal cancer. And mTORC2 in macrophages protects against CRC. Study published in JCI Insight (10/2019).
New Review from Jayne and Hannah: "Metabolic Programming of Macrophages: Implications in the Pathogenesis of Granulomatous Disease" published in Frontiers in Immunology (10/2019).
New Publication from Clarice and Alain Calender, Yves Pacheco, and the Group Sarcoidosis France: "Exome sequencing and pathogenicity-network analysis of 5 French families implicate mTOR signalling and autophagy in familial sarcoidosis." published in the European Respiratory Journal (05/2019).
New Review from Nima on the role of macrophages for iron metabolism and erythropoiesis. Published in a special issue of Pharmaceuticals on "Iron as Therapeutic Targets in Human Diseases". (12/2018)
A consortium consisting of Georg Stary (MUV, Department of Dermatology), Thomas Krausgruber (CeMM) and our lab was successful at the last Life Sciences Call 2018 from the WWTF termed "Linking Research & Patients Needs". Georg will coordinate the project termed "Systems medicine analysis of sarcoidosis by targeting mTOR in a co-clinical trial in patients and mice". (10/2018)
Nima won the award for the best oral presentation at the Congress of the European Macrophage & Dendritic Cell Society (EMDS) in Verona for her presentation on macrophages and iron metabolism. Congrats, Nima! (09/2018)
News & Views editorial from Jayne on a nice study by Sujin Kang and Atsushi Kumanogoh who link mTORC1 signaling to Semaphorin 6D and metabolic reprogrammig of macrophage polarization. (05/2018)
New paper out in Cell Reports from Thomas Karonitsch, where our lab had the possibility to contribute to this nice study. (05/2018)
New paper out in BMC Medical Genomics, in which Clarice had the possibility to contribute to this interesting study. (03/2018)
Our laboratory has been awarded a new FWF Grant from the Austrian Science Fund! (12/2017)
New review from the lab published in Gerontology entitled "mTOR as Regulator of Lifespan, Aging, and Cellular Senescence: A Mini-Review" (12/2017)
Monike Linke has won the Landsteiner Prize for the best basic immunological publication with her Nature Immunology paper. Congratulations! (11/2017)
New Review from Moni, Stephanie and Nima in a special issue of FEBS Letters: "Immunity and Metabolism"! (06/2017)
New Article in Cell Metabolism from Chantal describing different acitivites of High-Density Lipoproteins! (06/2017)
Nima received a prestigious DOC-Stipendium of the Austrian Academy of Sciences for her project on macrophages and iron metabolism. Congratulations! (05/2017)
We obtained funding for the creating, characterizing and improving a mouse model for sarcoidosis from the US-based patient organization "Foundation for Sarcoidosis Research". We are extremely happy and proud to contribute creating novel tools for sarcoidosis research. (04/2017)
Congratulation to Moni and all the others for the new publication in Nature Immunology on how Granulomas forms and develop. Including an editorial from Lalita Ramakrishnan! (03/2017)
Thomas Weichhart Lab at the Medical University of Vienna, Center for Pathobiochemistry & Genetics, Vienna, Austria