Stephi from the lab found that macrophages in the colon can act as “metabolic commensals”! They provide the metabolites spermidine and spermine to epithelial cells, which support their proliferation. A great collaborative project from the SFB Immunometabolism. Published in Cell Metabolism with a nice Preview from Jan Van den Bossche. (10/23)
Clarice together with Carlos Bueni-Beti from Angeliki Asimaki's lab at St. George's University of London describe the first in vivo model of cardiac sarcoidosis. Patients with cardiac sarcoidosis have mTOR activation as well! Published in the Journal of the American Heart Association. (09/23)
Andrea reviews the role of tissue-resident macrophages for tumor development and covers the many open questions that remain to be explored! Published in Current Opinion in Biotechnology. (08/23)
We are gratefule to the Ann Theodore Foundation, who supports research on our sarcoidosis mouse model through their Breakthrough Sarcoidosis Initiative! (07/2023)
New Finding from Nima in the lab: She and her colleagues identified a novel pathway regulating iron metabolism, demonstrating that mTORC1 controls macrophages in the lamina propria to induce local degradation of transferrin, thus limiting iron transfer from intestinal epithelial cells to the iron transport molecule transferrin. Published as cover image article in Blood with a nice commentary from Kostas Pantopoulos (06/2023)!
Clarice Lim won the Science Promotion Award of the Austrian Society of Pneumology (ÖGP). Her project on genetic predisposition in sarcoidosis is funded with an amount of € 15.000. Congratulations! (11/2022)
Hannah Mayr and Nyamdelger Sukhbaatar both won an Oral Presentation Award at the 17th YSA PhD Symposium of the Medical University of Vienna. Congratulations! (06/2022)
New Article from Clarissa: "p38 regulates the tumor suppressor PDCD4 via the TSC-mTORC1 pathway", where she identified that p38 regulates the tumor suppressor PDCD1 in macrophages via Tsc1 and Tsc2. Published in Cell Stress (12/2021)
New Review from Clarissa of the lab: "mTOR-dependent immunometabolism as Achilles' heel of anticancer therapy", where we discuss that targeting mTOR in cancer will affect metabolic functions of immune cells that either support or subvert antitumor responses. Published in European Journal of Immunology (11/2021)
Insights commentary from Clarice on an interesting study from Sarah Greaves, Andrew P. Fontenot, and colleagues that identify a peptide derived from an airborne mold species that stimulates T cells of Löfgren’s syndrome patients suggesting that the fungus Aspergillus nidulans might be the elusive microbial agent that drives acute sarcoidosis. Published in Journal of Experimental Medicine (09/2021)
Our laboratory has been successful to obtain another FWF Grant from the Austrian Science Fund to study the role of mTORC1 in intestinal diseases! (05/2021)
Our laboratory has been awarded a new FWF Grant from the Austrian Science Fund to study granulomas and disease in sarcoidosis! (03/2021)
The FWF has funded a new special research programme (SFB) focusing on "Immunometabolism". Our consortium consists of four research groups (Gerda Egger, Arvand Haschemi, Gernot Schabbauer and Thomas Weichhart) from the Medical University of Vienna. Elena Pohl works at VetmedUni Vienna. Participants from Graz are Martina Schweiger (Uni Graz) and Christine Moissl-Eichinger (MedUni Graz). Our lab will coordinate the project, which explores the metabolic maintenance of tissue integrity by macropahges.
New Review from Stephi: "Metabolic and immunologic control of intestinal cell function by mTOR" published in International Immunology (03/20)
New Opinion article from Clarice together with the lab of Alain Calender and Yves Pacheco: We hypothesize that defects in autophagy and mTOR-related pathways decrease the clearance of infectious as well as nonorganic particles and promote granuloma formation and Th17 differentiation in sarcoidosis. Published in Trends in Immunology (03/20)
New study from Jayne and Moni from the lab together with Thomas Nägele and Wolfram Weckwerth! We show that that Tsc2 influences the metabolome of macrophages. Inverse data-driven modeling and multiomics data reveal that Phgdh is an Tsc2-mTORC1-dependent metabolic checkpoint of macrophage proliferation and polarization. Phgdh is required for the expression of key anti-inflammatory molecules and M2 proliferation. Study published in Cell Reports (02/2020)
New study from Karl, Birgit and Stephi from the lab! We find mTORC2 activity mainly in macrophages but not tumor cells in colorectal cancer. And mTORC2 in macrophages protects against CRC. Study published in JCI Insight (10/2019).
New Review from Jayne and Hannah: "Metabolic Programming of Macrophages: Implications in the Pathogenesis of Granulomatous Disease" published in Frontiers in Immunology (10/2019).
New Publication from Clarice and Alain Calender, Yves Pacheco, and the Group Sarcoidosis France: "Exome sequencing and pathogenicity-network analysis of 5 French families implicate mTOR signalling and autophagy in familial sarcoidosis." published in the European Respiratory Journal (05/2019).
New Review from Nima on the role of macrophages for iron metabolism and erythropoiesis. Published in a special issue of Pharmaceuticals on "Iron as Therapeutic Targets in Human Diseases". (12/2018)
A consortium consisting of Georg Stary (MUV, Department of Dermatology), Thomas Krausgruber (CeMM) and our lab was successful at the last Life Sciences Call 2018 from the WWTF termed "Linking Research & Patients Needs". Georg will coordinate the project termed "Systems medicine analysis of sarcoidosis by targeting mTOR in a co-clinical trial in patients and mice". (10/2018)
Nima won the award for the best oral presentation at the Congress of the European Macrophage & Dendritic Cell Society (EMDS) in Verona for her presentation on macrophages and iron metabolism. Congrats, Nima! (09/2018)
News & Views editorial from Jayne on a nice study by Sujin Kang and Atsushi Kumanogoh who link mTORC1 signaling to Semaphorin 6D and metabolic reprogrammig of macrophage polarization. (05/2018)
New paper out in Cell Reports from Thomas Karonitsch, where our lab had the possibility to contribute to this nice study. (05/2018)
New paper out in BMC Medical Genomics, in which Clarice had the possibility to contribute to this interesting study. (03/2018)
Our laboratory has been awarded a new FWF Grant from the Austrian Science Fund! (12/2017)
New review from the lab published in Gerontology entitled "mTOR as Regulator of Lifespan, Aging, and Cellular Senescence: A Mini-Review" (12/2017)
Monike Linke has won the Landsteiner Prize for the best basic immunological publication with her Nature Immunology paper. Congratulations! (11/2017)
New Review from Moni, Stephanie and Nima in a special issue of FEBS Letters: "Immunity and Metabolism"! (06/2017)
New Article in Cell Metabolism from Chantal describing different acitivites of High-Density Lipoproteins! (06/2017)
Nima received a prestigious DOC-Stipendium of the Austrian Academy of Sciences for her project on macrophages and iron metabolism. Congratulations! (05/2017)
We obtained funding for the creating, characterizing and improving a mouse model for sarcoidosis from the US-based patient organization "Foundation for Sarcoidosis Research". We are extremely happy and proud to contribute creating novel tools for sarcoidosis research. (04/2017)
Congratulation to Moni and all the others for the new publication in Nature Immunology on how Granulomas forms and develop. Including an editorial from Lalita Ramakrishnan! (03/2017)
Thomas Weichhart Lab at the Medical University of Vienna, Center for Pathobiochemistry & Genetics, Vienna, Austria